Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice
Exercise training is anti-tumorigenic in a mouse model of luminal breast cancer, but the effect is abrogated by social isolation. The proteoglycan decorin is an exercise-induced secretory protein, and tumor decorin levels are positively associated with improved prognosis in patients. The hypothesis that elevated plasma decorin is a mechanism by which exercise training improves breast cancer progression in humans is not, however, supported by our pre-clinical data since elevated circulating decorin did not increase tumor decorin levels in these models.
Authors
- Surafel Tegegne (ORCID: https://orcid.org/0000-0002-3280-9117)
- Joanna N. Skhinas (ORCID: https://orcid.org/0000-0001-8797-8228)
- Tae Gyu Oh (ORCID: https://orcid.org/0000-0002-2756-3546)
- Marit Hjorth (ORCID: https://orcid.org/0000-0001-8067-714X)
- Erica K. Sloan (ORCID: https://orcid.org/0000-0002-2355-1433)
- Jesper Frank Christensen (ORCID: https://orcid.org/0000-0003-4858-1505)
- Mark A. Febbraio (ORCID: https://orcid.org/0000-0002-9296-4418)
- Julie Midtgaard (ORCID: https://orcid.org/0000-0003-2381-2127)
- Paul Gregorevic (ORCID: https://orcid.org/0000-0002-7418-8945)
- Hongwei Qian (ORCID: https://orcid.org/0000-0002-5991-6860)
- Martin Friedrichsen (ORCID: https://orcid.org/0000-0003-3383-9593)
- David Gallego‐Ortega (ORCID: https://orcid.org/0000-0002-2347-7835)
- Renato V. Iozzo (ORCID: https://orcid.org/0000-0002-5908-5112)
- Thomas R. Cox (ORCID: https://orcid.org/0000-0001-9294-1745)
- Emma Estévez (ORCID: https://orcid.org/0000-0002-5125-2190)
- Oliver K Fuller (ORCID: https://orcid.org/0000-0003-1914-922X)
- Kevin I. Watt (ORCID: https://orcid.org/0000-0001-7475-4487)
- Jørgen F. P. Wojtaszewski (ORCID: https://orcid.org/0000-0001-8185-3408)
- Matthew J. McKay (ORCID: https://orcid.org/0000-0002-3430-2467)
- Martin Pál (ORCID: https://orcid.org/0000-0002-1563-5426)
- Timothy E. Adams (ORCID: https://orcid.org/0000-0003-3436-0066)
- Brian G. Drew (ORCID: https://orcid.org/0000-0002-7839-9467)
- Mark P. Molloy (ORCID: https://orcid.org/0000-0003-4679-5868)
- Pernille Højman (ORCID: https://orcid.org/0000-0003-1206-8574)
- Casey L. Egan
- George E.O. Muscat (ORCID: https://orcid.org/0000-0002-5829-5695)
- Martin Whitham (ORCID: https://orcid.org/0000-0002-0254-762X)
- Emma McLennan (ORCID: https://orcid.org/0000-0002-0636-6447)
- Guilherme Defante Telles (ORCID: https://orcid.org/0000-0002-4179-0155)
- Ryan D. Gillis
- Michael S M Mah
Institutions
- Garvan Institute of Medical Research (AU)
- Thomas Jefferson University (US)
- The University of Queensland (AU)
- Copenhagen University Hospital (DK)
- CSIRO Manufacturing (AU)
Publication Details
- Journal
- Journal of sport and health science/Journal of Sport and Health Science
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1016/j.jshs.2024.100991
- Citations
- 10
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.83
Funders
- Monash University
- Medical Research Council
- National Health and Medical Research Council