Association of Undercorrection With Residual Proinflammatory Gene Expressions and Clinical Outcomes After Medial Open Wedge Proximal Tibial Osteotomy
The novel cutoff alignment for biological improvement after OWPTO in patients with medial compartment osteoarthritis was determined to be WBLR of 52%, and WBLR of <52% was associated with higher residual intra-articular inflammation and poor clinical outcomes. After accounting for surgical errors, the surgeon should set the target surgical alignment so that the postoperative WBLR does not fall below 52%.
Authors
- Kohei Nishitani (ORCID: https://orcid.org/0000-0002-8327-3826)
- Koichi Murata (ORCID: https://orcid.org/0000-0002-7896-3937)
- Yu Kobori (ORCID: https://orcid.org/0000-0003-3409-2348)
- Hiroyuki Yoshitomi (ORCID: https://orcid.org/0000-0001-7339-9030)
- Shigeo Yoshida (ORCID: https://orcid.org/0000-0003-1049-8909)
- Shinichi Kuriyama (ORCID: https://orcid.org/0000-0003-2526-2974)
- Shinichiro Nakamura (ORCID: https://orcid.org/0000-0003-1308-7080)
- Takayuki Fujii (ORCID: https://orcid.org/0000-0002-6556-1226)
- Shuichi Matsuda (ORCID: https://orcid.org/0000-0003-0802-1255)
Institutions
- Kyoto University (JP)
Publication Details
- Journal
- The American Journal of Sports Medicine
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1177/03635465241278748
- Primary Topic
- Total Knee Arthroplasty Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science