Empagliflozin attenuates hypoxia-induced heart failure of zebrafish embryos via influencing MMP13 expression
Our study shows that empagliflozin´s favorable effect on attenuating HF is mediated via MMP13. MMP13 provides a novel option when developing new therapeutics for HF treatment.
Authors
- Anne Jokilammi (ORCID: https://orcid.org/0000-0002-1675-5737)
- R Huttunen
- Hannu Järveläinen (ORCID: https://orcid.org/0000-0002-1061-6779)
- Anja Hjelt (ORCID: https://orcid.org/0000-0002-8039-8535)
- Ilkka Paatero (ORCID: https://orcid.org/0000-0001-5926-2396)
- A-M Haapanen-Saaristo
Institutions
- Åbo Akademi University (FI)
- University of Turku (FI)
- Turku Centre for Computer Science (FI)
- Satakunta Central Hospital (FI)
- Turku Centre for Biotechnology (FI)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1016/j.biopha.2024.117453
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Turun Yliopisto
- Biocenter Finland