Visible Light Photocatalyzed Norrish Type II Reaction of Acrylamides for the Synthesis of <i>β</i>‐Lactams
Abstract Here, we present a strategy for the visible‐light‐catalyzed synthesis of β ‐lactams based on the Norrish type II reaction. This protocol uses acetonitrile as solvent and commercially available photocatalyst to drive the reaction. Notably, various challenging substrate types reported in previous studies undergo conversion. DFT calculations further elucidate the reaction mechanism, while discussing the competitiveness between [2+2] cycloaddition and the Norrish II reaction.
Authors
- Xiu‐Long Yang (ORCID: https://orcid.org/0000-0003-3933-7738)
- Xiaoying Niu (ORCID: https://orcid.org/0000-0001-6779-2602)
- Qingyuan Meng (ORCID: https://orcid.org/0000-0002-2611-4271)
- S. K. Zhang
- Haoyuan Li (ORCID: https://orcid.org/0000-0002-2469-5842)
Institutions
- Chinese Academy of Sciences (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- University of Chinese Academy of Sciences (CN)
- Hebei University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1002/adsc.202400976
- Citations
- 4
- Primary Topic
- Synthesis of β-Lactam Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- Hebei University