Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Using data from seven cohort studies (N = 325,298) included in the multinational COVIDMENT consortium, and the Swedish registers (N = 8,080,234), this study investigates the association between mental illness (defined using self-report measures, clinical diagnosis and prescription data) and COVID-19 vaccination uptake. Results from the COVIDMENT cohort studies were pooled using meta-analyses, the majority of which showed no significant association between mental illness and vaccination uptake. In the Swedish register study population, we observed a very small reduction in the uptake of both the first and second dose of a COVID-19 vaccine among individuals with vs. without mental illness; the reduction was however greater among those not using psychiatric medication. Here we show that uptake of the COVID-19 vaccine is generally high among individuals both with and without mental illness, however the lower levels of vaccination uptake observed among subgroups of individuals with unmedicated mental illness warrants further attention.

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Publication Details

Journal
Nature Communications
Published
2024-09-26
DOI
https://doi.org/10.1038/s41467-024-52342-1
Citations
6
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
2.33

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article

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Kadri Kõiv, Kristjana Ásbjörnsdóttir, Unnur Anna Valdimarsdóttir, Arna Hauksdóttir et al.
6 citations
Nature Communications
SARS-CoV-2 and COVID-19 Research
2.33
article

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Kadri Kõiv, Kristjana Ásbjörnsdóttir, Unnur Anna Valdimarsdóttir, Arna Hauksdóttir, Ragnhild Eek Brandlistuen, Omid V. Ebrahimi, Fredrik Nyberg, Ole A. Andreassen, Maria Feychting, Bin Wang, Mary M. Barker, Helga Ask, Kelli Lehto, Archie Campbell, Gillian Murphy, Xinkai Du, Anikó Lovik, Anna K. Kähler, Daniel L. McCartney, Sverre Urnes Johnson, Emma M. Frans, Jóhanna Jakobsdóttir, Ingibjörg Magnúsdóttir, Asle Hoffart, Patrick F. Sullivan, Eva Herweijer, Gunnar Tómasson, Reedik Mägi, Huiqi Li, Emily E. Joyce, Thor Aspelund, Hannah Milbourn, Edda Bjork Thordardottir, Fang Fang, Elísabet U Gísladóttir
article en
6 citations

Abstract

Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Using data from seven cohort studies (N = 325,298) included in the multinational COVIDMENT consortium, and the Swedish registers (N = 8,080,234), this study investigates the association between mental illness (defined using self-report measures, clinical diagnosis and prescription data) and COVID-19 vaccination uptake. Results from the COVIDMENT cohort studies were pooled using meta-analyses, the majority of which showed no significant association between mental illness and vaccination uptake. In the Swedish register study population, we observed a very small reduction in the uptake of both the first and second dose of a COVID-19 vaccine among individuals with vs. without mental illness; the reduction was however greater among those not using psychiatric medication. Here we show that uptake of the COVID-19 vaccine is generally high among individuals both with and without mental illness, however the lower levels of vaccination uptake observed among subgroups of individuals with unmedicated mental illness warrants further attention.

Nature CommunicationsVol. 15(1)
University of North Carolina at Chapel Hill (US), Leiden University (NL), Reykjavík University (IS), Oslo University Hospital (NO), Norwegian Institute of Public Health (NO), Harvard University (US), University of Iceland (IS), University of Oslo (NO), Edinburgh Cancer Research (GB), Karolinska Institutet (SE), University of Oxford (GB), VID Specialized University (NO), University of Tartu (EE), University of Gothenburg (SE)
Wellcome, Wellcome Trust, Scottish Government, Scottish Funding Council, European Commission, Svenska Forskningsrådet Formas, Eesti Teadusagentuur, Helse- og Omsorgsdepartementet, Karolinska Institutet, Knut och Alice Wallenbergs Stiftelse, Vetenskapsrådet, NordForsk, Norges Forskningsråd, Forskningsrådet om Hälsa, Arbetsliv och Välfärd, Science for Life Laboratory, Horizon 2020 Framework Programme, Chief Scientist Office, Scottish Government Health and Social Care Directorate, European Regional Development Fund
Good health and well-being
Openalex Percentile: Top 11%
SARS-CoV-2 and COVID-19 Research
2.33
DOIOpen Access PDFOpenAlex
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