Effect of Tranexamic Acid Use on Estimated Blood Loss in Postpartum Hemorrhage

Objective: Postpartum hemorrhage is one of the most critical obstetric emergencies. This study aims to evaluate the effect of tranexamic acid on vital signs in cases of postpartum hemorrhage. Material and Method: In this retrospective case-control study, the vital and laboratory values of the patients were recorded at the time of initial hospitalization, and at 2 and 6 hours after delivery. Mean arterial pressure (MAP) was calculated as Diastolic Blood Pressure + 1/3 (Systolic Blood Pressure- Diastolic Blood Pressure). The 2nd and 6th hour ΔHb was determined as the difference between the admission Hb and the Hb at 2 and 6 hours, respectively. Patients who received tranexamic acid treatment were compared to those who did not, based on these data. Results: A total of 156 patients with postpartum hemorrhage who underwent cesarean section were included in our study. Of these patients, 83 received tranexamic acid treatment in addition to postpartum hemorrhage protocols and were included in the study group. The group that received the standard protocol without tranexamic acid treatment was included in the control group, consisting of 73 patients. The mean age of the patients in the study was 30.86±6.09 years, and the mean body mass index was 30.06±5.18 kg/m². Mean arterial pressure was higher in the study group compared to the control group (68.51±34.92 mm Hg vs. 56.20±40.33 mm Hg; p=0.001). The difference in hemogram values at 2 hours and 6 hours was significantly lower in the group that did not receive tranexamic acid compared to the study group (p=0.018, p=0.001). Conclusion: It was observed that the addition of tranexamic acid to the treatment of postpartum hemorrhage significantly increased the mean arterial pressure of the patients and resulted in notable differences in hemogram changes.