Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease
Greater self-reported weekly exercise predicts slower declines in brain volume in autosomal dominant Alzheimer's disease (ADAD). Greater self-reported weekly exercise predicts slower accumulation of brain amyloid beta in ADAD. Associations varied depending on closeness to estimated symptom onset.
Authors
- Tammie L.S. Benzinger (ORCID: https://orcid.org/0000-0002-8114-0552)
- James M. Noble (ORCID: https://orcid.org/0000-0003-0648-6702)
- Kirk I. Erickson (ORCID: https://orcid.org/0000-0001-8736-981X)
- Jee Hoon Roh (ORCID: https://orcid.org/0000-0002-3243-0529)
- Mathias Jucker (ORCID: https://orcid.org/0000-0001-9045-1072)
- Richard J. Perrin (ORCID: https://orcid.org/0000-0002-3443-7716)
- James D. Doecke (ORCID: https://orcid.org/0000-0003-2863-0293)
- Peter R. Schofield (ORCID: https://orcid.org/0000-0003-2967-9662)
- Nick C. Fox (ORCID: https://orcid.org/0000-0002-6660-657X)
- Randall John Bateman (ORCID: https://orcid.org/0000-0002-7729-1702)
- Sarah Berman (ORCID: https://orcid.org/0000-0002-5096-4962)
- Francisco Lopera (ORCID: https://orcid.org/0000-0003-3986-1484)
- Hamid R. Sohrabi (ORCID: https://orcid.org/0000-0001-8017-8682)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Charlene Supnet (ORCID: https://orcid.org/0000-0001-6917-770X)
- Jeremiah J. Peiffer (ORCID: https://orcid.org/0000-0002-3331-1177)
- Alisha Daniels (ORCID: https://orcid.org/0009-0001-1464-6465)
- Colin Louis Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Kelsey R. Sewell (ORCID: https://orcid.org/0000-0002-3859-5017)
- Samantha L. Gardener (ORCID: https://orcid.org/0000-0002-1933-5260)
- Stephanie Ruth Rainey‐Smith (ORCID: https://orcid.org/0000-0001-7328-9624)
- Jason J. Hassenstab (ORCID: https://orcid.org/0000-0002-7802-3371)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- John C. Morris (ORCID: https://orcid.org/0000-0001-9820-5618)
- Ralph N. Martins (ORCID: https://orcid.org/0000-0002-4828-9363)
- Ricardo Allegri (ORCID: https://orcid.org/0000-0001-7166-1234)
- Eric McDade (ORCID: https://orcid.org/0000-0002-6764-3866)
- Laura Ibáñez (ORCID: https://orcid.org/0000-0003-2381-7059)
- Edward D. Huey (ORCID: https://orcid.org/0000-0002-8295-5884)
- Belinda M. Brown (ORCID: https://orcid.org/0000-0001-7927-2540)
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Brian A. Gordon (ORCID: https://orcid.org/0000-0003-2109-2955)
- Jorge J. Llibre‐Guerra (ORCID: https://orcid.org/0000-0002-2137-7750)
- Jae‐Hong Lee (ORCID: https://orcid.org/0000-0001-7368-4560)
- Christoph Laske
- Chengjie Xiong (ORCID: https://orcid.org/0009-0003-8949-2629)
Institutions
- Ulsan College (KR)
- Edith Cowan University (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- The University of Melbourne (AU)
- University of Pittsburgh (US)
- Murdoch University (AU)
- Korea University (KR)
- Washington University in St. Louis (US)
- Florey Institute of Neuroscience and Mental Health (AU)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Korea University Medical Center (KR)
- German Center for Neurodegenerative Diseases (DE)
- Jacksonville College (US)
- Asan Medical Center (KR)
- LMU Klinikum (DE)
- UNSW Sydney (AU)
- Universidad de Antioquia (CO)
- University of Ulsan (KR)
- Massachusetts General Hospital (US)
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (AR)
- Munich Cluster for Systems Neurology (DE)
- UK Dementia Research Institute (GB)
- Australian e-Health Research Centre (AU)
- Hertie Institute for Clinical Brain Research (DE)
- Mayo Clinic in Florida (US)
- Australian Alzheimer’s Research Foundation (AU)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Neuroscience Research Australia (AU)
- Macquarie University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1002/alz.14270
- Citations
- 5
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Alzheimer's Association
- Brigham and Women's Hospital
- Massachusetts General Hospital
- Washington University in St. Louis
- University of Pittsburgh
- Fondation Brain Canada
- Japan Agency for Medical Research and Development
- Hope Center for Neurological Disorders
- Korea Dementia Research Center
- Murdoch University
- Korea Health Industry Development Institute
- University of Tokyo
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Ministry of Science and ICT, South Korea
- Fleni
- School of Medicine, Indiana University
- Irving Medical Center, Columbia University
- Canadian Institutes of Health Research
- Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis
- Fonds de Recherche du Québec - Santé
- Instituto de Salud Carlos III
- National Institute on Aging