A million-cow genome-wide association study of productive life in U.S. Holstein cows
The GWAS results showed that highly significant genetic effects for PL were in chromosome regions known to have highly significant effects for fertility and health and a chromosome region with multiple genes with reproductive and immunity functions. SNPs with rare but sharply negative homozygous recessive genotypes for PL existed and should be used for eliminating heifers carrying those homozygous recessive genotypes.
Authors
- Dzianis Prakapenka (ORCID: https://orcid.org/0000-0002-4592-7120)
- P.M. VanRaden (ORCID: https://orcid.org/0000-0002-9123-7278)
- Hafedh Ben Zaabza (ORCID: https://orcid.org/0000-0003-4648-3813)
- Curtis P. Van Tassell (ORCID: https://orcid.org/0000-0002-8416-2087)
- Zuoxiang Liang (ORCID: https://orcid.org/0000-0002-9058-9327)
- Yang Da (ORCID: https://orcid.org/0000-0003-0119-7928)
Institutions
- University of Minnesota (US)
- Agricultural Research Service (US)
Publication Details
- Journal
- Genetics Selection Evolution
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1186/s12711-024-00935-1
- Citations
- 6
- Primary Topic
- Genetic and phenotypic traits in livestock
- Type
- article
- Field-Weighted Citation Impact
- 3.30
Funders
- National Science Foundation
- U.S. Department of Agriculture
- University of Minnesota
- National Institutes of Health
- National Institute of Food and Agriculture
- Agricultural Research Service
- National Human Genome Research Institute