Parthenolide ameliorates 3-nitropropionic acid-induced Huntington’s disease-like aberrations via modulating NLRP3 inflammasome, reducing microglial activation and inducing astrocyte shifting
PTL exhibits neuroprotection against 3NP-induced HD, that might be ascribed, at least in part, to its modulatory effects on Keap1/Nrf2 and NF-κB/NLRP3 inflammasome signaling.
Authors
- Heba R. Ghaiad (ORCID: https://orcid.org/0000-0003-4765-0353)
- Nancy N. Shahin (ORCID: https://orcid.org/0000-0002-9746-5335)
- Hebat Allah A. Amin (ORCID: https://orcid.org/0000-0003-3311-4840)
- Maha M. El‐Sawalhi (ORCID: https://orcid.org/0000-0002-6598-4392)
- Mona E Noureldeen (ORCID: https://orcid.org/0009-0005-6679-7862)
Institutions
- Cairo University (EG)
- Helwan University (EG)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1186/s10020-024-00917-5
- Citations
- 22
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.90
Funders
- Cairo University