Associations between the multitrajectory neuroplasticity of neuronavigated rTMS‐mediated angular gyrus networks and brain gene expression in AD spectrum patients with sleep disorders
This was the first transcription-neuroimaging study to demonstrate that multitrajectory neuroplasticity in neural circuits was induced via neuronavigated rTMS, which was associated with complex gene expression in AD-spectrum patients with sleep disorders. The interactions between sleep quality and neuronavigated rTMS were coupled with multiple gene pathways and improvements in episodic memory. The present strategy for integrating neuroimaging, rTMS intervention, and genetic data provide a new approach to comprehending the biological mechanisms involved in AD.
Authors
- Tingyu Lv
- Weina Yao
- Xinle Hou (ORCID: https://orcid.org/0000-0002-4273-4614)
- Zhiyuan Yang (ORCID: https://orcid.org/0000-0002-2695-254X)
- Shengqi You
- Haifeng Chen (ORCID: https://orcid.org/0000-0002-5455-9876)
- Feng Bai (ORCID: https://orcid.org/0000-0002-0164-9552)
- Huijuan Zhou (ORCID: https://orcid.org/0000-0002-3696-6232)
- Chang Chen (ORCID: https://orcid.org/0000-0003-1849-5649)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Wuhan University (CN)
- Nanjing Drum Tower Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1002/alz.14255
- Citations
- 3
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing University