APPLICATION OF MATRIX SOLID-PHASE DISPERSION COMBINED WITH GAS CHROMATOGRAPHY-MASS SPECTROMETRY FOR THE DETERMINATION OF BISPHENOL A IN FRESH-WATER FISHES

Matrix solid-phase dispersion using of a humate-based magnetic sorbent is proposed as an ef f cient method for the concentration of bisphenol A from f sh muscular and hepatic tissue samples followed by the chromatography-mass spectrometry determination of analyte pre-derivatized with acetic anhydride. Under the optimum concentration conditions (the stirring time was 10 min and the sorbent weight was 0.05 g), the recovery of bisphenol A upon single sorption reached 85%. The percentage desorption exceeded 99% (the eluate was methanol, the time was 3 min, and the volume was 1 mL). The maximum concentration factor was 718. The limit of detection of bisphenol A was 0.15 μ g/kg (on dry basis) for the muscular tissue and 0.25 μ g/kg for liver.