Relative Effectiveness and Immunogenicity of Quadrivalent Recombinant Influenza Vaccine Versus Egg-Based Inactivated Influenza Vaccine Among Adults Aged 18–64 Years: Results and Experience From a Randomized, Double-Blind Trial
Relative VE of RIV compared to SD IIV did not reach statistical significance, but RIV elicited more robust humoral immune responses to 2 of 4 vaccine viruses at 1 month and 3 of 4 viruses at 6 months after vaccination, suggesting possible improved and sustained immune protection from RIV. <b>Clinical Trials Registration.</b> NCT05514002.
Authors
- Jacob Mckell (ORCID: https://orcid.org/0009-0003-0585-0311)
- Fatimah S. Dawood (ORCID: https://orcid.org/0000-0002-6609-376X)
- E. Nuez Zaragoza
- Hana M. El Sahly (ORCID: https://orcid.org/0000-0003-0489-0074)
- Rebecca V. Fink (ORCID: https://orcid.org/0000-0003-3255-4756)
- Jennifer A. Whitaker (ORCID: https://orcid.org/0000-0002-7727-6086)
- Jesse Feiring Williams
- Jennifer K. Meece (ORCID: https://orcid.org/0000-0002-6486-3505)
- Fornessa T. Randal
- Sarah W. Ball (ORCID: https://orcid.org/0000-0002-0903-8107)
- Matthew S. Thiese (ORCID: https://orcid.org/0000-0003-4505-2907)
- Riley Campbell (ORCID: https://orcid.org/0000-0002-0613-4507)
- Kristina Wielgosz (ORCID: https://orcid.org/0000-0001-6006-5963)
- Lenee Blanton (ORCID: https://orcid.org/0000-0002-6791-4312)
- Andrew L. Phillips (ORCID: https://orcid.org/0000-0003-2320-3567)
- Sarang K. Yoon (ORCID: https://orcid.org/0000-0002-8500-2886)
- Kurt T. Hegmann (ORCID: https://orcid.org/0000-0002-0743-1888)
- John Barnes (ORCID: https://orcid.org/0000-0002-5874-4411)
- Ashley A. Lowe (ORCID: https://orcid.org/0000-0001-6252-0368)
- Lauren Grant (ORCID: https://orcid.org/0000-0002-8656-3538)
- Min Z. Levine (ORCID: https://orcid.org/0000-0002-3197-1649)
- Karen Lutrick (ORCID: https://orcid.org/0000-0003-3480-849X)
- Alia Southworth
- Alicia M. Fry (ORCID: https://orcid.org/0000-0002-3208-9308)
- Steph Battan-Wraith (ORCID: https://orcid.org/0000-0002-8097-1653)
- Rachel M. Brown
- Tanya Tatum
- Julie Mayo-Lamberte
- C Perry Brown
- Catherine Healy
- S. K. Bhargava
Institutions
- Centers for Disease Control and Prevention (US)
- Westat (United States) (US)
- University of Arizona (US)
- Baylor College of Medicine (US)
- University of Utah (US)
- University of Chicago (US)
- Asian Health Coalition (US)
- CVS Health (United States) (US)
- Marshfield Clinic (US)
- Florida Agricultural and Mechanical University (US)
- Rocky Mountain University of Health Professions (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1093/ofid/ofae559
- Citations
- 8
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- Emory University
- National Institutes of Health
- Centers for Disease Control and Prevention