DNA Methylation-Derived Immune Cell Proportions and Cancer Risk in Black Participants
This study describes associations between immune cell types and cancer risk in a Black population; elevated regulatory T-cell proportions that were associated with increased overall cancer and lung cancer risk, and elevated memory B-cell proportions that were associated with increased prostate and all cancer risk.
Authors
- Jan Bressler (ORCID: https://orcid.org/0000-0001-6578-4772)
- Elizabeth A. Platz (ORCID: https://orcid.org/0000-0003-3676-8954)
- Rachel J. Buchsbaum (ORCID: https://orcid.org/0000-0003-2502-9240)
- Eric Boerwinkle (ORCID: https://orcid.org/0000-0001-8813-0544)
- Devin C. Koestler (ORCID: https://orcid.org/0000-0002-0598-0146)
- Karl T. Kelsey (ORCID: https://orcid.org/0000-0002-2302-1600)
- Naisi Zhao (ORCID: https://orcid.org/0000-0002-0517-0709)
- Christopher S. Semancik (ORCID: https://orcid.org/0000-0002-9915-9091)
- Dominique S. Michaud (ORCID: https://orcid.org/0000-0002-8107-3011)
Institutions
- Tufts University (US)
- Tufts Medical Center (US)
- Johns Hopkins University (US)
- Baylor College of Medicine (US)
- Brown University (US)
- The University of Kansas Cancer Center (US)
- University of Kansas Medical Center (US)
- Baylor Genetics (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0257
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- U.S. Department of Health and Human Services
- Tufts Medical Center
- Centers for Disease Control and Prevention