Doxycycline versus Curcumin for Inhibition of Matrix Metalloproteinase Expression and Activity Following Chemically Induced Inflammation in Corneal Cells
Doxycycline and curcumin can inhibit MMP expression and activity in chemically exposed corneal cells. Curcumin has a greater ability than doxycycline to inhibit MMP-2 and MMP-9 enzymes; however, the difference is statistically significant only in the case of MMP-9. After further validation, these substances can be introduced as anti- inflammatory agents to treat corneal chemical burns.
Authors
- Ali Razei (ORCID: https://orcid.org/0000-0001-6863-928X)
- Rouhollah Ameri (ORCID: https://orcid.org/0000-0003-4310-7847)
- Alireza Shahriary (ORCID: https://orcid.org/0000-0003-3240-9591)
- Hossein Aghamollaei (ORCID: https://orcid.org/0000-0003-4275-8613)
- Mahdi Fasihi‐Ramandi (ORCID: https://orcid.org/0000-0002-8242-4880)
- Hamed Zareh
Institutions
- Baqiyatallah University of Medical Sciences (IR)
- Mashhad University of Medical Sciences (IR)
- Academic Center for Education, Culture and Research (IR)
- Motamed Cancer Institute (IR)
Publication Details
- Journal
- Journal of Ophthalmic and Vision Research
- Published
- 2024-09-16
- DOI
- https://doi.org/10.18502/jovr.v19i3.13689
- Citations
- 1
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Baqiyatallah University of Medical Sciences