ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway
ATF6 intervention reduces colorectal cancer cell and organoid viability by interrupting dysregulated Wnt signaling, identifying a novel facilitator and potential therapeutic target in colorectal cancer.
Authors
- Tamal Sarkar (ORCID: https://orcid.org/0009-0003-7053-530X)
- Elisia Villemure (ORCID: https://orcid.org/0000-0002-0902-5189)
- Whitney Shatz-Binder (ORCID: https://orcid.org/0000-0003-2996-501X)
- Thomas D. Wu (ORCID: https://orcid.org/0000-0003-4505-4531)
- Avi Ashkenazi (ORCID: https://orcid.org/0000-0002-6890-4589)
- Ioanna Oikonomidi (ORCID: https://orcid.org/0000-0003-1657-962X)
- Joachim Rudolph (ORCID: https://orcid.org/0000-0002-0806-6106)
- Jonathan M. Harnoss (ORCID: https://orcid.org/0000-0002-4272-5769)
- Karen Ruiz (ORCID: https://orcid.org/0000-0002-8083-7630)
- Jeffrey J. Rodvold (ORCID: https://orcid.org/0000-0002-4873-210X)
- Felipe de Sousa e Melo (ORCID: https://orcid.org/0000-0002-9558-3098)
- Jennie R. Lill (ORCID: https://orcid.org/0000-0002-7142-253X)
- Victoria C. Pham (ORCID: https://orcid.org/0009-0009-9281-8806)
- Zora Modrušan (ORCID: https://orcid.org/0009-0003-5647-5195)
- Scot A. Marsters (ORCID: https://orcid.org/0000-0002-8517-0994)
- Matthew Grimmer (ORCID: https://orcid.org/0000-0001-5184-9168)
- Eileen Tan-Aristy
Institutions
- Microsemi (Canada) (CA)
- Universitätsklinikum Gießen und Marburg (DE)
- Discovery Centre (CA)
- Genesys (United States) (US)
- Sunesis (United States) (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0268
- Citations
- 9
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.93