Fluoroalkenes as biomolecules isosteres; preparation and application: a personal account

Fluoroalkenes have been known for decades, but their preparation is still a hot topic. Indeed, the olefination reactions of carbonyl compounds with fluorinated derivatives are not trivial. For that reason, new tools have been developed to efficiently access tri- and tetrasubstituted alkenes. We report our contribution in this field and their interest will be illustrated by the preparation of dipeptide isosteres and acyclonucleoside analogues.