A multicenter evaluation of a novel microfluidic rapid AST assay for Gram-negative bloodstream infections
Increasing antimicrobial resistance underscores the need for new diagnostic solutions to guide therapy, but traditional antimicrobial susceptibility testing (AST) is often inadequate in time-critical diseases such as sepsis. This work presents a novel and rapid AST system with a rapid turnaround of results, which may help reduce the time to guided therapy, possibly allowing early de-escalation of broad-spectrum empirical therapy as well as rapid adjustments to treatments when coverage is lacking.
Authors
- Håkan Öhrn
- Jonas Ångström (ORCID: https://orcid.org/0000-0002-4752-5491)
- Jenny Fernberg
- Benjamin Berinson (ORCID: https://orcid.org/0000-0003-2749-1201)
- Linnea Flinkfeldt
- Emma Davies (ORCID: https://orcid.org/0000-0001-5075-9742)
- Holger Rohde (ORCID: https://orcid.org/0000-0001-8587-4433)
- Martin Sundqvist (ORCID: https://orcid.org/0000-0003-3750-6075)
- Christer Malmberg (ORCID: https://orcid.org/0000-0003-3187-8732)
- Cecilia Johansson (ORCID: https://orcid.org/0000-0001-5965-2853)
- J. Bergqvist
- Jessie Torpner
- Amanda Åman
- Helena Andersson
- Teresa Fernandez-Zafra
- Maria Rolf
- Klara Jäder
- Ehsan Ghaderi
Institutions
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Universität Hamburg (DE)
- Örebro University (SE)
- University Medical Center Hamburg-Eppendorf (DE)
- Gradientech (Sweden) (SE)
- Örebro University Hospital (SE)
Publication Details
- Journal
- Journal of Clinical Microbiology
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1128/jcm.00458-24
- Citations
- 9
- Primary Topic
- Bacterial Identification and Susceptibility Testing
- Type
- article
- Field-Weighted Citation Impact
- 3.43
Funders
- Tillväxtverket