Immunity and Protective Efficacy of a Plant-Based Tobacco Mosaic Virus-like Nanoparticle Vaccine against Influenza a Virus in Mice
Our findings indicate that TMV-HA and HA-con protein vaccines with adjuvant induce protective immune responses against influenza A virus infections. Furthermore, our results underscore the potential of plant-based production using TMV-like nanoparticles for developing influenza A virus candidate vaccines.
Authors
- Richard J. Webby (ORCID: https://orcid.org/0000-0002-4397-7132)
- Eric A. Weaver (ORCID: https://orcid.org/0000-0002-5029-0662)
- Adthakorn Madapong (ORCID: https://orcid.org/0000-0003-4007-4920)
- Erika Petro-Turnquist (ORCID: https://orcid.org/0000-0001-7532-2256)
- Alison A. McCormick (ORCID: https://orcid.org/0000-0002-9567-5128)
Institutions
- University of Nebraska–Lincoln (US)
- St. Jude Children's Research Hospital (US)
- Touro University California (US)
Publication Details
- Journal
- Vaccines
- Published
- 2024-09-26
- DOI
- https://doi.org/10.3390/vaccines12101100
- Citations
- 5
- Primary Topic
- Transgenic Plants and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases