Elevated serum circulating cell‐free mitochondrial <scp>DNA</scp> in amyotrophic lateral sclerosis
Our study found increased serum ccf-mtDNA in ALS patients, suggesting a link to inflammatory processes and disease mechanism. Moreover, ccf-mtDNA could be an indicator for ALS progression, especially in those with the SOD1 mutation.
Authors
- Zhiying Xie
- Yiming Zheng (ORCID: https://orcid.org/0000-0001-7993-3054)
- Jianwen Deng (ORCID: https://orcid.org/0000-0003-1206-1778)
- Meng Yu (ORCID: https://orcid.org/0000-0003-0234-5902)
- He Lv (ORCID: https://orcid.org/0000-0002-4148-625X)
- Yun Yuan (ORCID: https://orcid.org/0000-0003-3282-9123)
- Jing Liu (ORCID: https://orcid.org/0000-0002-9728-8893)
- Lingchao Meng
- Qingqing Wang (ORCID: https://orcid.org/0000-0002-5846-2801)
- Zhaoxia Wang (ORCID: https://orcid.org/0000-0002-8723-4242)
- Yawen Zhao (ORCID: https://orcid.org/0000-0002-7585-3329)
- Jieyu Li (ORCID: https://orcid.org/0000-0001-8868-6905)
- Chao Gao (ORCID: https://orcid.org/0000-0002-7484-2732)
- Wei Zhang
Institutions
- Peking University (CN)
- National Health and Family Planning Commission (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1111/ene.16493
- Citations
- 8
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.95
Funders
- Peking University First Hospital
- National Natural Science Foundation of China
- Peking University
- Beijing Nova Program