Insect Cuticle Protein Nanoassemblies without Nonspecific Immune Response for Acute Methicillin-Resistant <i>Staphylococcus aureus</i> Pneumonia Remission
The emergence and proliferation of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) pneumonia poses a significant global public health threat. Herein, the significant remission effect against acute MRSA pneumonia was realized through the insect cuticle protein (<i>Of</i><b>CPH-2</b>) nanoassemblies without nonspecific immune response. The lung repair results could be attributed to the transforming of M1-type to M2-type macrophage polarization and the repression of Th17 cell differentiation in mice spleens through the intervention of <i>Of</i><b>CPH-2</b> nanoassemblies. These findings offer a valuable insight into the application of insect protein-based materials as effective antidrug resistant strain agents as well as a powerful strategy for acute MRSA pneumonia.
Authors
- Xiaoyan Zeng (ORCID: https://orcid.org/0000-0002-1107-7965)
- Qiuyu Gong
- Runyi Tao
- Yinjuan Huang (ORCID: https://orcid.org/0000-0003-4974-6818)
- Mei Yang (ORCID: https://orcid.org/0000-0003-2661-5188)
- Fenghou Yuan (ORCID: https://orcid.org/0009-0000-8709-262X)
- Jizhao Wang (ORCID: https://orcid.org/0000-0002-5379-2481)
- Guangjian Zhang (ORCID: https://orcid.org/0000-0003-0663-6256)
- Jiaqi Huang (ORCID: https://orcid.org/0000-0003-4637-9928)
- Qian Wang
- Tian Liu (ORCID: https://orcid.org/0000-0001-9768-5496)
- Ye Sun (ORCID: https://orcid.org/0000-0002-3755-0853)
- Xingzhuo Zhu
- Bohao Liu (ORCID: https://orcid.org/0000-0003-1092-5341)
- Deqian Qiao
Institutions
- Qingdao University of Science and Technology (CN)
- Dalian University of Technology (CN)
- Dalian University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1021/acsabm.4c01084
- Citations
- 3
- Primary Topic
- Insect and Pesticide Research
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- National Natural Science Foundation of China
- Xi’an Jiaotong University
- Qingdao University of Science and Technology
- Key Research and Development Projects of Shaanxi Province