Antifungal Susceptibilities of Candida Species Isolated to Clinical Samples

Background: Candidiasis is a skin, mucosal, and organ infection caused by Candida fungi, with Candida albicans being the most common.These infections pose significant morbidity and mortality risks, necessitating rapid identification and characterization methods for diagnosis and personalized antifungal therapy based on Candida's pathogenic properties. Materials and Methods:Candida species isolated from diverse clinical samples from patients were included in this study.A total of 86 isolates were analyzed at the genus and species levels using mass spectrometry, while susceptibility profiles to amphotericin B (AmB), anidulafungin (AND), fluconazole (FLC), and voriconazole were regulated using the gradient test method.Results: Candida spp.were detected in 1254 clinical samples obtained from 736 patients.Antifungal susceptibility was tested on 86 isolated samples, including C. albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, Candida kefyr, Candida guilliermondii, and Candida krusei.The corresponding rates of resistance to AmB and FLC in C. albicans isolates were 2.2% and 13.3%.No resistance to AND was determined. Conclusion:Candida species C. albicans is the most regularly isolated, but infections from other Candida species have increased.No resistance to AND was observed, but species-specific resistance to other antifungal agents was identified, emphasizing the need for continuous monitoring.