Methyl 6,7-Difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate
A convenient synthesis of a novel fluoroquinolone precursor, methyl 6,7-difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate, at a 78% yield starting from 3,4-difluorophenyl isothiocyanate was developed. The structure of the product was established by 1H, 13C, and 19F NMR spectroscopy, mass spectrometry, IR spectroscopy and confirmed by elemental analysis. The title compound, containing the pharmacophoric 4-fluorobenzyl group, will be used in the synthesis of novel fluoroquinolone derivatives.
Authors
- М. В. Мусалов (ORCID: https://orcid.org/0000-0002-7638-8377)
- В. А. Потапов (ORCID: https://orcid.org/0000-0002-3151-6726)
- С. В. Амосова (ORCID: https://orcid.org/0000-0002-2874-3725)
- Олег А. Ракитин (ORCID: https://orcid.org/0000-0001-6609-4087)
- Irina A. Novokshonova
Institutions
- N.D. Zelinsky Institute of Organic Chemistry (RU)
- A.E. Favorsky Irkutsk Institute of Chemistry (RU)
Publication Details
- Journal
- Molbank
- Published
- 2024-09-26
- DOI
- https://doi.org/10.3390/m1889
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Siberian Branch, Russian Academy of Sciences
- Russian Science Foundation