Fractional Doses of Pneumococcal Conjugate Vaccine — A Noninferiority Trial
In a three-dose schedule (two primary doses and a booster), 40% doses of PCV13 were noninferior to full doses for all included serotypes. Lower doses of PCV13 and PCV10 did not meet the criteria for noninferiority. (Funded by the Bill and Melinda Gates Foundation and others; ClinicalTrials.gov number, NCT03489018; Pan African Clinical Trial Registry number, PACTR202104717648755.).
Authors
- J. Anthony G. Scott (ORCID: https://orcid.org/0000-0001-7533-5006)
- Fred Were (ORCID: https://orcid.org/0000-0001-7879-1883)
- Mark Otiende (ORCID: https://orcid.org/0000-0002-1389-1813)
- Jimmy Shangala
- Angela Karani (ORCID: https://orcid.org/0000-0002-1076-8713)
- Laura Mwalekwa (ORCID: https://orcid.org/0000-0001-8207-4967)
- Mary Kaniu
- James Alexander Berkley (ORCID: https://orcid.org/0000-0002-1236-849X)
- Elizabeth Gardiner
- Daisy Mugo (ORCID: https://orcid.org/0000-0003-3128-2461)
- Sarah Ragab
- Ruth Lucinde (ORCID: https://orcid.org/0000-0001-6926-8556)
- Peter G. Smith (ORCID: https://orcid.org/0000-0003-0080-7560)
- Mainga Hamaluba (ORCID: https://orcid.org/0000-0002-0266-1414)
- Christian Bottomley (ORCID: https://orcid.org/0000-0002-5241-8412)
- Katherine E. Gallagher (ORCID: https://orcid.org/0000-0002-5604-7647)
- Collins Tabu (ORCID: https://orcid.org/0000-0002-0537-1172)
- Badaud Suaad
- Mary Mutahi
- Louise Twi-Yeboah
- David Goldblatt (ORCID: https://orcid.org/0000-0002-0769-5242)
Institutions
- University of London (GB)
- University College London (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1056/nejmoa2314620
- Citations
- 9
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 3.48
Funders
- Bill and Melinda Gates Foundation
- Wellcome Trust
- National Institute for Health and Care Research
- Medical Research Council