Use of the senolytics dasatinib and quercetin for prevention of pelvic organ prolapse in a mouse animal model
D+Q injections did not result in clinically significant differences in prolapse development but did demonstrate decreased expression of cellular senescence markers in <i>Fbln-5<sup>-/-</sup></i> mice. This suggests senolytic agents may mitigate contributions of cellular senescence to tissue dysfunction associated with prolapse. Further studies are needed to confirm ideal timing, dosage, and route of senolytics in prevention of prolapse.
Authors
- Maria Florian‐Rodriguez (ORCID: https://orcid.org/0000-0002-5835-2266)
- Jessica Pruszynski (ORCID: https://orcid.org/0000-0001-9019-3229)
- Erryn Tappy (ORCID: https://orcid.org/0000-0002-8271-1249)
- Haolin Shi (ORCID: https://orcid.org/0000-0002-4883-9265)
Institutions
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Aging
- Published
- 2024-09-26
- DOI
- https://doi.org/10.18632/aging.206120
- Citations
- 2
- Primary Topic
- Pelvic floor disorders treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- University of Texas Southwestern Medical Center