Single-cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID
A single-cell transcriptomic landscape of the small airways suggest that neutrophils may play a significant role in mediating the chronic small airway inflammation driving pulmonary symptoms of long COVID.
Authors
- Jonathon A Leipsic (ORCID: https://orcid.org/0000-0002-6133-8334)
- Stephen B Milne (ORCID: https://orcid.org/0000-0001-5274-1298)
- Elizabeth Guinto (ORCID: https://orcid.org/0000-0002-4239-0006)
- Graeme J. Koelwyn (ORCID: https://orcid.org/0000-0002-3476-0919)
- Rachel L. Eddy (ORCID: https://orcid.org/0000-0002-2541-1645)
- Don D. Sin (ORCID: https://orcid.org/0000-0002-0756-6643)
- Hong Dang (ORCID: https://orcid.org/0000-0002-7305-4208)
- Tawimas Shaipanich (ORCID: https://orcid.org/0000-0001-5551-0073)
- Chen Xi Yang (ORCID: https://orcid.org/0000-0002-8033-4769)
- Clarus Leung (ORCID: https://orcid.org/0000-0003-3515-7537)
- Tara Stach (ORCID: https://orcid.org/0000-0002-5611-6139)
- Dina Yehia
- Hye Yun Park (ORCID: https://orcid.org/0000-0002-5937-9671)
- Firoozeh V. Gerayeli (ORCID: https://orcid.org/0000-0003-3353-8408)
- Chung Yan Cheung (ORCID: https://orcid.org/0009-0005-5948-3881)
- Seyed Milad Vahedi (ORCID: https://orcid.org/0000-0002-5846-2107)
- Josie Tuong
- Xuan Li (ORCID: https://orcid.org/0009-0004-1337-3049)
- Janice M. Leung (ORCID: https://orcid.org/0000-0003-1682-6483)
- Cassie Gilchrist
- Julia Sw Yang
Institutions
- University of North Carolina at Chapel Hill (US)
- University of British Columbia Hospital (CA)
- The University of Sydney (AU)
- New York City Fire Department (US)
- University of British Columbia (CA)
- Simon Fraser University (CA)
- St. Paul's Hospital (CA)
- Samsung Medical Center (KR)
- Health First (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1183/13993003.01947-2023
- Citations
- 17
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 7.12
Funders
- Genome British Columbia
- Mitacs
- University of British Columbia
- Canadian Institutes of Health Research