Methanolic Extract of Cimicifuga foetida Induces G1 Cell Cycle Arrest and Apoptosis and Inhibits Metastasis of Glioma Cells
CF-ME exhibited potent anti-glioma activity through multiple mechanisms, including cell cycle arrest, apoptosis, autophagy, and the inhibition of metastasis. Combining CF-ME with TMZ further enhanced its therapeutic potential, making it a promising candidate for adjuvant therapy in glioblastoma treatment.
Authors
- Hung‐Pei Tsai (ORCID: https://orcid.org/0000-0001-9170-6268)
- Chien‐Ju Lin (ORCID: https://orcid.org/0000-0001-5224-3539)
- Chih-Hsuan Chang
- Ming-Hong Yen
Institutions
- Kaohsiung Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
Publication Details
- Journal
- Nutrients
- Published
- 2024-09-26
- DOI
- https://doi.org/10.3390/nu16193254
- Citations
- 4
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Science and Technology Council