EZH2-Mediated H3K27 Trimethylation in the Liver of Mice Is an Early Epigenetic Event Induced by High-Fat Diet Exposure
In conclusion, we point to EZH2/H3K27me3 as an early epigenetic event occurring in fatty-acid-challenged livers both in vivo and in vitro, thus establishing EZH2 as a potential pharmacological target for metabolic derangements.
Authors
- Laura Moro (ORCID: https://orcid.org/0000-0002-4657-0557)
- Giulia Dematteis (ORCID: https://orcid.org/0000-0002-6317-3182)
- Fausto Chiazza (ORCID: https://orcid.org/0000-0001-7273-0051)
- Nausicaa Clemente (ORCID: https://orcid.org/0000-0002-9860-0148)
- Gabriela Chrostek (ORCID: https://orcid.org/0000-0002-5235-1561)
- Giulia Pinton (ORCID: https://orcid.org/0000-0003-0496-0378)
- Dmitry Lim (ORCID: https://orcid.org/0000-0002-4316-2654)
- Justyna Malecka (ORCID: https://orcid.org/0009-0002-1950-3364)
- Mattia Perucca
- Valentina Gigliotti
- Elena Mantovani
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
Publication Details
- Journal
- Nutrients
- Published
- 2024-09-26
- DOI
- https://doi.org/10.3390/nu16193260
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.47