The Tumor Immune Microenvironment Drives Survival Outcomes and Therapeutic Response in an Integrated Molecular Analysis of Gastric Adenocarcinoma
We conclude that the TME score is a predominate driver of prognosis as well as chemotherapy- and immunotherapy-related outcomes in gastric cancer. This article provides a foundation for additional analyses and translational work.
Authors
- Daniel Skubleny (ORCID: https://orcid.org/0000-0001-8243-6139)
- Jennifer L. Spratlin (ORCID: https://orcid.org/0000-0003-3304-1784)
- Gina R. Rayat (ORCID: https://orcid.org/0000-0003-1450-7892)
- Michael McCall (ORCID: https://orcid.org/0000-0002-5617-6457)
- Kieran Purich (ORCID: https://orcid.org/0000-0002-6166-2564)
- Dan Schiller (ORCID: https://orcid.org/0000-0001-7190-5198)
- Sunita Ghosh (ORCID: https://orcid.org/0000-0002-9763-5058)
- Sebastião N. Martins-Filho (ORCID: https://orcid.org/0000-0002-6123-2601)
- Klaus Buttenschoen (ORCID: https://orcid.org/0000-0002-3958-1135)
- David R. McLean (ORCID: https://orcid.org/0000-0002-2220-5213)
- Erika Haase
Institutions
- University of Alberta (CA)
- Royal Alexandra Hospital (CA)
- Alberta Cancer Foundation (CA)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1158/1078-0432.ccr-23-3523
- Citations
- 9
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- Edmonton Civic Employees Charitable Assistance Fund
- Canadian Institutes of Health Research