ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1α
RD results in the activation of ERS, mitophagy, mitochondrial dysfunction, and accumulation of polyubiquitinated proteins. Results suggest a role for HIF1α in activation of the mitophagy pathway after RD, which may serve to protect the PR cells.
Authors
- Bruna Miglioranza Scavuzzi (ORCID: https://orcid.org/0000-0001-9609-001X)
- Jingyu Yao (ORCID: https://orcid.org/0000-0002-4506-9541)
- Bhavneet Kaur
- Steven F. Abcouwer (ORCID: https://orcid.org/0000-0003-2580-1288)
- Lin Jia (ORCID: https://orcid.org/0009-0001-5820-663X)
- Meng-Ling Yang (ORCID: https://orcid.org/0000-0002-4141-9049)
- David Zacks
Institutions
- University of Michigan (US)
- Michigan United (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1167/iovs.65.11.39
- Citations
- 6
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.40