Determinants of Prognosis in Head and Neck Cutaneous Squamous Cell Carcinoma With Nodal Metastases
The study results suggest that immunosuppression, perineural invasion, ENE, and size and number of nodal metastases are associated with reduced survival and LRC in HNcSCC with nodal metastases. The inclusion of ENE in HNcSCC staging needs to be reassessed, as it ascribes excessive importance to ENE and upstages most patients to TNM stage IV, despite many having a high chance of cure.
Authors
- Lachlan McDowell (ORCID: https://orcid.org/0000-0002-4268-3079)
- Klaus‐Martin Schulte (ORCID: https://orcid.org/0000-0002-9091-0512)
- Sandro Porceddu (ORCID: https://orcid.org/0000-0003-0937-6939)
- Paul N. Smith (ORCID: https://orcid.org/0000-0001-6891-5694)
- Michael Veness
- Ardalan Ebrahimi (ORCID: https://orcid.org/0000-0002-5433-3965)
- Allan Fowler (ORCID: https://orcid.org/0000-0003-1061-5511)
- Matthew J. R. Magarey (ORCID: https://orcid.org/0000-0002-0296-4060)
- Tsu‐Hui Low (ORCID: https://orcid.org/0000-0001-8958-736X)
- Ruta Gupta (ORCID: https://orcid.org/0000-0003-2940-313X)
- Diana M. Perriman (ORCID: https://orcid.org/0000-0003-1632-1768)
- Jonathan R. Clark (ORCID: https://orcid.org/0000-0003-1209-772X)
Institutions
- Australian National University (AU)
- The University of Sydney (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Royal Prince Alfred Hospital (AU)
- Peter MacCallum Cancer Centre (AU)
- Liverpool Hospital (AU)
- Princess Alexandra Hospital (AU)
- Canberra Hospital (AU)
- Westmead Hospital (AU)
- Chris O’Brien Lifehouse (AU)
- ACT Government (AU)
Publication Details
- Journal
- JAMA Otolaryngology–Head & Neck Surgery
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1001/jamaoto.2024.3103
- Citations
- 6
- Primary Topic
- Nonmelanoma Skin Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.32