Comprehensive analysis of the cerebrospinal fluid and serum metabolome in neurological diseases
These findings outline the landscape of the CSF and serum metabolome in different categories of neurological diseases and identify age and blood-brain-barrier function as relevant co-factors for CSF levels of certain metabolites. Metabolome profiles as determined by NMR spectroscopy may potentially aid in differentiating groups of patients with different neurological diseases, including clinically meaningful differentiations, such as Parkinson's disease from other neurodegenerative diseases.
Authors
- Andrea A. Kühn (ORCID: https://orcid.org/0000-0002-4134-9060)
- Steffen Heelemann (ORCID: https://orcid.org/0000-0001-5104-8774)
- Johannes Wittmann (ORCID: https://orcid.org/0000-0003-4488-1711)
- Dorothee Kübler (ORCID: https://orcid.org/0000-0001-5097-0281)
- Carolin Otto (ORCID: https://orcid.org/0000-0002-9768-5143)
- Rea Kalantzis
- Armin Regler
- Selina Strathmeyer (ORCID: https://orcid.org/0009-0006-6074-5268)
- Klemens Ruprecht
- Tina Böld
Institutions
- Humboldt-Universität zu Berlin (DE)
- Maschinenfabrik Reinhausen (Germany) (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1186/s12974-024-03218-0
- Citations
- 21
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.75
Funders
- Charité – Universitätsmedizin Berlin