Nickel-Catalyzed Reductive Dicarbofunctionalization of 1,3-Dienes with Aziridines and (Het)Aryl Electrophiles
A three-component reductive 1,4-dicarbofunctionalization of 1,3-dienes with aziridines and (het)aryl electrophiles was realized. The combination of Ni catalysis with Mn powder as a final reductant enables the direct formation of a Csp<sup>2</sup>-Csp<sup>3</sup> and a Csp<sup>3</sup>-Csp<sup>3</sup> bond at one time. This protocol afforded a convenient approach to the synthesis of β-arylethylamines bearing various functionals and heterocyclic groups. The utility of this reaction was also demonstrated by scale-up preparation, late-stage modification of bioactive molecules, and diverse transformations.
Authors
- Jie-Rui Zhang
- Hua-Jiao Ding
- Bi‐Qin Wang
- Bin Zhang (ORCID: https://orcid.org/0000-0003-3172-8056)
- Bin Chen (ORCID: https://orcid.org/0000-0002-9907-7002)
- Peng Cao (ORCID: https://orcid.org/0000-0001-8199-0015)
- Ping Hu
- Zhang-Li Shang
- Minghui Xu (ORCID: https://orcid.org/0000-0003-3444-8332)
Institutions
- Sichuan Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1021/acs.orglett.4c02983
- Citations
- 4
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province