Spatial transcriptomics reveal tumor microenvironment and SLCO2A1 correlated with tumor suppression in hypopharyngeal squamous cell carcinoma
We investigated tumor and fibroblast heterogeneity, as well as the immune microenvironment in HSCC by using spatial transcriptomics. SLCO2A1 may be a tumor suppressor gene and correlates with immune infiltration for HSCC and could serve as a potential target for its diagnosis and treatment.
Authors
- yin wang
- Ran Wei (ORCID: https://orcid.org/0000-0002-5121-3650)
- Dapeng Lei (ORCID: https://orcid.org/0000-0001-5637-3509)
- Dongmin Wei (ORCID: https://orcid.org/0000-0001-6872-162X)
- Shengda Cao
- Fen Chang
- Neil D. Gross (ORCID: https://orcid.org/0000-0002-9427-0743)
- Zinan Li
- Guojun Li (ORCID: https://orcid.org/0000-0001-9505-1502)
- Rui Guan (ORCID: https://orcid.org/0000-0002-4450-2817)
- Ce Li (ORCID: https://orcid.org/0009-0009-8037-550X)
- Wenming Li (ORCID: https://orcid.org/0000-0002-8396-9110)
- Chenyang Xu (ORCID: https://orcid.org/0000-0003-2790-933X)
- Zhiwei Liu
- C. Cui
- Ruijie Jiao
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.intimp.2024.113243
- Citations
- 6
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- National Natural Science Foundation of China