The Curative Hypolipidemic Effect, Antioxidant Activity, and Atherogenic Indexes of Methanolic Extract of Arbutus Pavarii Leaves

The aim of the study was to investigate the antioxidant activity and curative effect of (MEAPL) and its role in the treatment of hypercholesterolemia in male albino rats. The effect of (MEAPL) against hypercholesterolemia in rats was analyzed via examination of various types of parameters, (LDL), (HDL), (TC), and (TG), also liver enzymes (ALT, AST, G-GT, LDH, and ALP) besides proteins and MDA. Antioxidant enzymes (SOD, GR, GPx, and CAT), were measured in control and (HFD). We have found that the level of TC, LDL, TG, and liver enzymes were increased but the level of HDL decreased in HFD rats compared with control. Lipid peroxidation was determined by the level of MDA, which increased in HFD compared with control while antioxidant enzymes SOD, GR, GPx, and CAT were decreased. The results obtained revealed that MEAPL has a healing effect against hypercholesterolemia compared with the reference standard agent ˝Atorvastatin˝ and standard antioxidant vitamin C.