Evaluation of the Efficacy of Helicobacter pylori Eradication Regimens

Background: Several studies have been carried out to assess the effectiveness of current combination therapies for H. pylori infection. Usually, a PPI is combined with two antibiotics (triple therapy) or bismuth salts are added to these three medication agents (quadruple therapy). Antibiotic selection ought to be region-specific, taking into account local H. pylori resistance to those drugs. Aim of the Study: The objective is to evaluate and compare the efficacy of treatment regimens for H. pylori infection. Methods: A retrospective cohort study will be conducted at the Gastroenterology department at King Hussein Medical Centre in The Royal Medical Services, Amman, Jordan. Electronic health records (Hakeem) will be accessed for data extraction. Inclusion criteria will be patients who were diagnosed with H. pylori infection and received one of the two prescribed eradication regimens. Regimen A consists of two doses of 1 g amoxicillin capsules and 40 mg esomeprazole capsules twice a day for 14 days, in addition to a 500 mg levofloxacin tablet once a day while regimen B consists of 500 mg clarithromycin tablets, 500 mg metronidazole tablets, and 40 mg esomeprazole capsules taken twice daily. Exclusion Criteria include patients with incomplete medical records or those with contraindications to standard eradication therapies. Version 24 of the Statistical Package for the Social Sciences (SPSS) will be used to code and analyse the data. Results: We enrolled 62 patients in the levofloxacin-based regimen and in the clarithromycin-based therapy distributed equally among the two study groups. The former was successful in 27 patients (43.5%) and the latter in 20 patients (32.3%), using chi-square test (P < .05). Regimen A had greater eradication rates than regimen B in the current investigation, with 87% and 64.5% eradication rates, respectively. Conclusion: A levofloxacin–amoxycillin-based triple therapy has been proved to be acceptably effective as second- or even ..........