Frequency of Carbapenem Resistance in UTI Patients in a Tertiary Level Hospital

Background: Urinary tract infections (UTIs) remain the common infections diagnosed in outpatients as well as hospitalized patients. Current knowledge on antimicrobial susceptibility pattern is essential for appropriate therapy. Extended-Spectrum Beta-Lactamase (ESBL) producing bacteria may not be detected by routine disk diffusion susceptibility test, leading to inappropriate use of antibiotics and treatment failure. The aim of this study was to determine the distribution and antibiotic susceptibility patterns of bacterial strains isolated from patients with community acquired urinary tract infections (UTIs) at Comilla Medical College Hospital, Comilla as well as identification of ESBL producers in the population of different uropathogens. Objectives: To obseve the frequency of carbapenem resistance in UTI patients in a tertiary level hospital. Methods: This cross sectional observational study was done on inpatients and outpatients department of Comilla Medical College Hospital, Comilla in 6 months’ period. Formal ethical approval was taken before commencement of the study. Adult patients presenting with features of UTI were approached and finally selected in accordance to selection criteria. Convenience sampling technique was applied to enroll the total 100 study population. Following describing the purpose, methods and benefits of study written consent was taken from each patient. All patients were subjected to detail history, clinical examination and relevant investigation. Value of clinical investigations were noted on questionnaire. Following data collection, all were verified and prepared for data entry. Final analysis was done by using SPSS version 19. Results: Out of 100 patients attending in Comilla Medical College Hospital with symptoms suggestive of UTI, 31% had culture positive. Our study showed a high prevalence of UTI in females (61%) than in males (39%). Most common symptom was urgency (88%) followed by abdominal pain (77%), dysuria (67%) and ........