New Insights Into Antibacterial And Antitumor Effects Of Structurally Versatile Amino Acid- Based And Non-Proteinogenic Compounds

The honey bee (Apis mellifera) has been known to mankind since ancient times.The last few decades, honey bee populations have been declining dramatically worldwide due to various causes including pesticides, bacterial diseases and parasites [1].That leads to a pressing problem with a huge global economic, environmental, social, and public health impact.The American Foulbrood disease (AFB) is an infection that still belong to the most deleterious honey bee diseases (Fig. 1) [1,2].Herein we investigate the cytotoxic potential of new small molecules against the Gram-positive bacterium Paenibacillus larvae, the causative agent of the American Foulbrood disease (AFB).Furthermore, we were interested to study the activity of these compounds against different cancer cell lines.