Cyclic peptides as Connexin43 and Pannexin1 inhibitors for the treatment of inflammatory disorders
0.9% NaCl BIOLOGICAL ACTIVITYAt 5 M, all the cyclic peptides have an inhibitory activiity comparable to that of CT1 without a CPP.SBL-Cx43-125 retains its activity at a concentration as low as 100 nM.The length of the linker affects activity of the lipidated peptides SBL-Cx43-157 shows a higher inhibitory capacity compared to the peptide based on CT10 (SBL-Cx43-135).
Authors
- Steven Ballet (ORCID: https://orcid.org/0000-0003-4123-1641)
- Filippo Molica (ORCID: https://orcid.org/0000-0002-0405-5397)
- Malaury Tournier
- Arthur Lamouroux (ORCID: https://orcid.org/0000-0002-7045-7060)
- Anne Caufriez (ORCID: https://orcid.org/0000-0001-6656-2178)
- Mathieu Vinken (ORCID: https://orcid.org/0000-0001-5115-8893)
- Brenda R. Kwak (ORCID: https://orcid.org/0000-0003-0015-0044)
- Jade Montgomery
- Debora Iaculli
Publication Details
- Published
- 2024-09-20
- DOI
- https://doi.org/10.17952/37eps.2024.p2065
- Primary Topic
- Human Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00