Synthesis and antimicrobial activity of hybrid peptides as dual inhibitor of intracellular targets in ESKAPE pathogens

The infections caused by ESKAPE pathogens are a global challenge in clinical settings due to their multidrug resistance and even last-resort antibiotics ineffective for treatment.Advances in science have shown that bacteria adapt and mutate to resist antibiotics.To combat this, new antibiotics with novel targets and mechanisms are needed.Antimicrobial peptides (AMPs), which have evolved over millennia as natural antimicrobial agents and immune response mediators, are one of the promising candidates in this fight.