Esc peptides for novel therapeutics against Pseudomonas aeruginosa pulmonary infections: beyond antimicrobial activity

Esc peptides for novel therapeutics against Pseudomonas aeruginosa pulmonary infections: beyond antimicrobial activityRecently, the ability of Esc peptides to increase the F508del CFTR-mediated transepithelial conductance (TEEC) was studied in combination with FSK.This effect was higher for Esc-1C at 10 M and comparable to that of GEN when used at the same concentration (Figure 2).We also found that this effect is highly dependent on the primary structure of Esc peptides and the presence of Ser-17 (Figure 3).The CFTR potentiating activity of Esc peptides was well preserved in primary airway epithelial cells from homozygous F508del patients (Figure 4).