Genetic and biochemical characterization of OXA-1186, a novel OXA-198-type carbapenemase hydrolysing cephalosporins in <i>Citrobacter freundii</i>
Here, we described a novel carbapenemase, OXA-1186, identified in C. freundii. Unlike OXA-198, OXA-1186 is able to hydrolyse broad-spectrum cephalosporins. This carbapenemase was carried on a broad-spectrum IncP6 plasmid identified in other Citrobacter species and non-fermenters.
Authors
- Delphine Girlich (ORCID: https://orcid.org/0000-0002-7698-2798)
- Agnès B. Jousset (ORCID: https://orcid.org/0000-0002-8223-2213)
- Saoussen Oueslati (ORCID: https://orcid.org/0000-0001-5766-3831)
- Thierry Naas (ORCID: https://orcid.org/0000-0001-9937-9572)
- Laurent Dortet (ORCID: https://orcid.org/0000-0001-6596-7384)
- Rémy A. Bonnin (ORCID: https://orcid.org/0000-0002-2307-3232)
- Océane Vanparis
- Anne Delaval
- C. Guyot
Institutions
- Inserm (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- CEA Paris-Saclay (FR)
- CNR de la Résistance aux Antibiotiques (FR)
- Groupe Hospitalier Intercommunal Le Raincy Montfermeil (FR)
- Bicêtre Hospital (FR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1093/jac/dkae339
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Assistance Publique - Hôpitaux de Paris
- Université Paris-Saclay
- Assistance publique-Hôpitaux de Paris