Mouse cortical organoids reveal key functions of p73 isoforms: TAp73 governs the establishment of the archetypical ventricular-like zones while DNp73 is central in the regulation of neural cell fate

Organoids derived from p73-deficient cells exhibited increased neuronal apoptosis and reduced neural progenitor proliferation, linked to compensatory activation of p53. This closely mirrors previous <i>in vivo</i> observations, confirming that p73 plays a pivotal role in brain development. Further dissection of p73 isoforms function revealed a dual role of p73 in regulating brain morphogenesis, whereby TAp73 controls transcriptional programs essential for the establishment of the neurogenic niche structure, while DNp73 is responsible for the precise and timely regulation of neural cell fate. These findings highlight the distinct roles of p73 isoforms in maintaining the balance of neural progenitor cell biology, providing a new understanding of how p73 regulates brain morphogenesis.

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Publication Details

Journal
Frontiers in Cell and Developmental Biology
Published
2024-09-23
DOI
https://doi.org/10.3389/fcell.2024.1464932
Citations
3
Primary Topic
Pluripotent Stem Cells Research
Type
article
Field-Weighted Citation Impact
0.70

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article

Mouse cortical organoids reveal key functions of p73 isoforms: TAp73 governs the establishment of the archetypical ventricular-like zones while DNp73 is central in the regulation of neural cell fate

Anna Prieto‐Colomina, Margarita M. Marqués, Vı́ctor Borrell, Lorena López‐Ferreras et al.
3 citations
Frontiers in Cell and Developmental Biology
Pluripotent Stem Cells Research
0.70
article

Mouse cortical organoids reveal key functions of p73 isoforms: TAp73 governs the establishment of the archetypical ventricular-like zones while DNp73 is central in the regulation of neural cell fate

Anna Prieto‐Colomina, Margarita M. Marqués, Vı́ctor Borrell, Lorena López‐Ferreras, Nicole Martínez‐García, Rosalía Fernández-Alonso, María C. Marín, Hugo Alonso-Olivares, Alberto Vázquez-Jiménez
article en
3 citations

Abstract

Organoids derived from p73-deficient cells exhibited increased neuronal apoptosis and reduced neural progenitor proliferation, linked to compensatory activation of p53. This closely mirrors previous <i>in vivo</i> observations, confirming that p73 plays a pivotal role in brain development. Further dissection of p73 isoforms function revealed a dual role of p73 in regulating brain morphogenesis, whereby TAp73 controls transcriptional programs essential for the establishment of the neurogenic niche structure, while DNp73 is responsible for the precise and timely regulation of neural cell fate. These findings highlight the distinct roles of p73 isoforms in maintaining the balance of neural progenitor cell biology, providing a new understanding of how p73 regulates brain morphogenesis.

Frontiers in Cell and Developmental BiologyVol. 12
Universitat de Miguel Hernández d'Elx (ES), Instituto de Neurociencias (ES), Instituto de Ganadería de Montaña (ES), Universidad de León (ES)
Fundación Tatiana Pérez de Guzmán el Bueno, Junta de Castilla y León, Agencia Estatal de Investigación
Openalex Percentile: Top 30%
Pluripotent Stem Cells Research
0.70
DOIOpen Access PDFOpenAlex
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