Role of IL-6 in Physiology and Pathology of the Ovary

Objective: We aimed to explore the roles of interleukin (IL)-6 in ovarian physiology and pathology. Mechanism: IL-6 is a common and important cytokine in numerous physiological and pathological processes. Findings in Brief: In the ovary, IL-6 is secreted by granulosa cells, and involved in many crucial physiological functions, including normal ovulation and menstrual cycle, hormone secretion, egg cell maturation, and even in the fertilization process of egg cells. The abnormal secretion of IL-6 is associated with premature ovarian failure, polycystic ovary syndrome and ovarian cancer. Conclusions: This review will summarize existing clues and explore the key roles of IL-6 in ovarian physiology and pathology, which will provide new targets for the treatment of common ovarian diseases.