USP15-Mediated Deubiquitination of FKBP 5 and Activation of the αIIbβ3 Signaling Pathway Regulate Thrombosis in Mice
USP15 knockdown in platelets affects thrombosis in mice by promoting the instability of FKBP5 to repress the activation of IKBKE/PI3K/Rap1 pathway-mediated αIIbβ3.
Authors
- Qiyong Wu (ORCID: https://orcid.org/0000-0002-6281-5622)
- Ziwei Guo (ORCID: https://orcid.org/0000-0003-1378-9517)
- LI Pei-jin (ORCID: https://orcid.org/0009-0006-5163-1402)
- Ming Zhang (ORCID: https://orcid.org/0000-0002-8610-3048)
- Xuejiao Li (ORCID: https://orcid.org/0000-0002-1061-2161)
- Bin Zhong
- Zehui Shi
- Sixu Bao
Institutions
- Dalian Medical University (CN)
- Changzhou No.2 People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-09-20
- DOI
- https://doi.org/10.31083/j.fbl2909325
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00