SGO2 as a Prognostic Biomarker Correlated with Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition in Lung Adenocarcinoma

Our study demonstrated that <i>SGO2</i> was up-regulated in pan-cancers including LUAD and its high expression was strongly associated with poor overall survival (OS) and progression-free survival (PFS) of patients with LUAD. <i>SGO2</i> promoted cell proliferation, cell migration, invasion and EMT of A549 cells. Additionally, <i>E2F1</i> was involved in regulation of cell cycle and cell proliferation mediated by <i>SGO2</i>. This research elucidated the oncogenic significance of <i>SGO2</i> in LUAD, proposing its potential as a prognostic biomarker and a promising target for therapeutic interventions.

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Publication Details

Journal
Frontiers in Bioscience-Landmark
Published
2024-08-30
DOI
https://doi.org/10.31083/j.fbl2909314
Citations
2
Primary Topic
Phytochemical Studies and Bioactivities
Type
article
Field-Weighted Citation Impact
0.47

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article

SGO2 as a Prognostic Biomarker Correlated with Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition in Lung Adenocarcinoma

Tingxiu Xiang, Yinghua Chen
2 citations
Frontiers in Bioscience-Landmark
Phytochemical Studies and Bioactivities
0.47
article

SGO2 as a Prognostic Biomarker Correlated with Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition in Lung Adenocarcinoma

Tingxiu Xiang, Yinghua Chen
article en
2 citations

Abstract

Our study demonstrated that <i>SGO2</i> was up-regulated in pan-cancers including LUAD and its high expression was strongly associated with poor overall survival (OS) and progression-free survival (PFS) of patients with LUAD. <i>SGO2</i> promoted cell proliferation, cell migration, invasion and EMT of A549 cells. Additionally, <i>E2F1</i> was involved in regulation of cell cycle and cell proliferation mediated by <i>SGO2</i>. This research elucidated the oncogenic significance of <i>SGO2</i> in LUAD, proposing its potential as a prognostic biomarker and a promising target for therapeutic interventions.

Frontiers in Bioscience-LandmarkVol. 29(9)
Chongqing University (CN), The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), Chongqing Medical University (CN)
National Natural Science Foundation of China, Chongqing Science and Technology Commission
No poverty
Openalex Percentile: Top 35%
Phytochemical Studies and Bioactivities
0.47
DOIOpen Access PDFOpenAlex
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SGO2 as a Prognostic Biomarker Correlated with Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition in Lung Adenocarcinoma — Tingxiu Xiang, Yinghua Chen · Frontiers in Bioscience-Landmark (2024) | TGRS Research Map | TGRS