Microbiota-derived tryptophan metabolism and AMPK/mTOR pathway mediate antidepressant-like effect of Shugan Hewei Decoction
SHD may exert antidepressant-like effects by regulating microbiota-derived tryptophan metabolism, and triggering the AMPK/mTOR pathway of autophagy, enhancing the intestinal barrier function.
Authors
- Yingying Yue (ORCID: https://orcid.org/0000-0002-0099-4901)
- Junping Zheng (ORCID: https://orcid.org/0000-0002-9134-572X)
- Hongtao Liu (ORCID: https://orcid.org/0000-0003-0149-6389)
- Songlin Liu (ORCID: https://orcid.org/0000-0001-5321-9864)
- Zicheng Wang (ORCID: https://orcid.org/0000-0001-7514-6029)
- Youlan Ke
Institutions
- Hubei University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.3389/fphar.2024.1466336
- Citations
- 12
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.89
Funders
- Health Commission of Hubei Province
- Natural Science Foundation of Hubei Province