Study on pharmacokinetic and tissue distribution of hyperin, astragalin, kaempferol-3-O-β-D-glucuronide from rats with multiple administrations of Semen Cuscutae processed with salt solution with effect of treating recurrent spontaneous abortion
This study reveals the pharmacokinetics and tissue distribution of KA, AS and HY in rats with RSA. It was elucidated that all three were involved in the regulation of progesterone levels and immune function. It initially revealed the mechanism of action of YP in enhancing the improvement of RSA, and it provided a theoretical basis for the quality assessment of YP.
Authors
- Deling Wu (ORCID: https://orcid.org/0000-0001-6027-0625)
- Zhitong Yang
- Tulin Lu (ORCID: https://orcid.org/0000-0003-4096-9249)
- Tongsheng Wang (ORCID: https://orcid.org/0000-0003-0840-407X)
- Zilu Liu (ORCID: https://orcid.org/0000-0003-2387-3587)
- Tangyi Peng
- Yuting Zhang (ORCID: https://orcid.org/0000-0002-9820-0072)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-5782-2174)
- Kaiwen Chen (ORCID: https://orcid.org/0000-0001-8815-0641)
- Xiaoli Wang (ORCID: https://orcid.org/0000-0001-6015-857X)
- Baiyang Xu
- Yu Huang
- Hao Cai (ORCID: https://orcid.org/0009-0002-3395-6538)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.3389/fphar.2024.1440810
- Citations
- 3
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Natural Science Foundation of China
- Anhui University
- Anhui University of Chinese Medicine