Subthreshold amyloid deposition, cerebral small vessel disease, and functional brain network disruption in delayed cognitive decline after stroke
Disruptions in modular structures, system segregation, and inter-network communication in the brain may be the pathophysiological underpinnings of delayed-onset PSCD. WMHs and subthreshold amyloid deposition could contribute to these disruptions in functional brain networks. Given the limited number of patients and potential residual confounding, our results should be considered hypothesis-generating and need replication in larger cohorts in the future.
Authors
- SangYun Kim (ORCID: https://orcid.org/0000-0002-9101-5704)
- Philip B. Gorelick (ORCID: https://orcid.org/0000-0002-1181-614X)
- Jae‐Sung Lim (ORCID: https://orcid.org/0000-0001-6157-2908)
- Wi‐Sun Ryu (ORCID: https://orcid.org/0000-0002-2823-5253)
- Dong Woo Shin (ORCID: https://orcid.org/0000-0002-3398-3707)
- Min Jae Baek (ORCID: https://orcid.org/0000-0001-8215-6081)
- Jae‐Joong Lee (ORCID: https://orcid.org/0000-0002-7353-8683)
- Geon Ha Kim (ORCID: https://orcid.org/0000-0001-5395-1924)
- Jinyong Chung
- Dong‐Eog Kim (ORCID: https://orcid.org/0000-0002-9339-6539)
- Hee‐Joon Bae (ORCID: https://orcid.org/0000-0003-0051-1997)
- Beom Joon Kim (ORCID: https://orcid.org/0000-0002-2719-3012)
- Eunvin Ko (ORCID: https://orcid.org/0009-0002-4459-5782)
- Keon-Joo Lee
- Hang-Rai Kim
- Choong-Wan Woo
Institutions
- Northwestern University (US)
- Ewha Womans University (KR)
- Korea University (KR)
- Dongguk University (KR)
- Korea University Medical Center (KR)
- Asan Medical Center (KR)
- Seoul National University Bundang Hospital (KR)
- Institute for Basic Science (KR)
- Dongguk University Ilsan Hospital (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-09-16
- DOI
- https://doi.org/10.3389/fnagi.2024.1430408
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Seoul National University Bundang Hospital