Comparative Studies of Benzimidazoles Synthetic Routes and its Biological Activity

: Benzimidazole, discovered in 1872, is a heterocyclic compound noted for its pharmacological activities. It and its derivatives can be synthesized through methods such as condensation reactions and using nano-based nanoparticles as catalysts. Recent environmentally friendly methods include microwaves, ultrasound, and photochemical reactions. its derivatives are known for their diverse medicinal applications : Benzimidazole and its derivatives are versatile compounds with a wide range of pharmacological activities. Their synthesis has evolved over time, incorporating various environmentally friendly methods such as microwave, ultrasound, and photochemical reactions. The continued exploration of these compounds and their synthesis methods holds great promise for the development of new and effective medicinal applications. : Here, we provide an overview of benzimidazole, highlighting its historical significance, various synthesis methods, and extensive range of pharmacological activities. It aims to emphasize the importance of benzimidazole and its derivatives in medicinal chemistry and their potential therapeutic applications. The review also notes the development of environmentally friendly synthesis techniques, reflecting advancements in the field.