Association of Diabetes Mellitus with Salivary Secretor Status of ABO Blood Group

Diabetes mellitus (DM) is a metabolic disease which has a genetic predisposition, ABH secretor status is also genetically pre-determined and therefore we studied the association between secretor status of ABO & Rh blood group with diabetes mellitus. This case control study was conducted in the department of Physiology and collaborated with General Medicine at Maharaja Agrasen Medical College, Agroha, Hisar. Total 200 study subjects of both males and females of age between 30-60 years were selected to conduct the study. They were divided in two groups i.e. confirmed 100 non-diabetic subjects as control group and confirmed 100 diabetics as study group.ABO and Rh blood group was determined by slide agglutination method and presence or absence of water soluble ABH blood group antigens in saliva by Haemagglutination inhibition technique. Out of 100 diabetic subjects, 76 were secretors and 24 were non secretors and out of 100 non diabetic subjects, 81 were secretors and 19 were non secretors.There was statistically no significant correlation found between secretor status with diabetes mellitus (p=0.389). In ourstudy, we found significant association of non-secretors of B blood group with diabetes mellitus (p=0.01). Our study concluded that the non-secretors of B blood group were more prone to diabetes mellitus.